In turn, this “activates” brand new azide for nucleophilic assault (5)

In turn, this “activates” brand new azide for nucleophilic assault (5)

On following the action, N(1) displaces among ligands regarding next Cu about Cu-acetylide advanced to create 3. Because of proximity and you will digital things, N(3) are now able to with ease assault C(cuatro) of one’s alkyne, resulting in an effective metallocycle (maybe not found to possess ease). The newest metallocycle upcoming deals in the event that solitary pair of electrons regarding N(1) symptoms C(5) in order to create new particular triazole 4. Once 4 versions, this new connected Cu dimer immediately complexes to help you the second terminal alkyne. Yet not, it next alkyne you should never experience an effective cycloaddition considering the undesirable construction of state-of-the-art, also it dissociates up on protonation so you can reform cuatro. Continue reading “In turn, this “activates” brand new azide for nucleophilic assault (5)”